Scaling laws in velocity-selective coherent-population-trapping laser cooling

One-dimensional laser cooling based on velocity-selective coherent population trapping (VSCPT) has been investigated numerically through the solution of the optical Bloch equations and through a Monte Carlo analysis. The 1→1 and 2→2 transitions have been examined as a function of the atomic recoil frequency, the spontaneous-emission decay rate, and the Rabi frequency of the cooling laser. It has been found that for a large set of those parameters, the VSCPT cooling process may be described through scaling-law relations. The scaling laws are not valid at long atom-laser interaction times or large Rabi frequencies, where the atomic Doppler shift plays a significant role in the atomic motion evolution. Similar results for two atomic transitions suggest the validity of the scaling law for any one-dimensional VSCPT process

Geschlechterstereotype und Geschlechterrollen

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Synthesis and configurational assignment of vinyl sulfoximines and sulfonimidamides

Vinyl sulfones and sulfonamides are valued for their use as electrophilic warheads in covalent protein inhibitors. Conversely, the S(VI) aza-isosteres thereof, vinyl sulfoximines and sulfonimidamides, are far less studied and have yet to be applied to the field of protein bioconjugation. Herein, we report a range of different synthetic methodologies for constructing vinyl sulfoximine and vinyl sulfonimidamide architectures that allows access to new areas of electro-philic chemical space. We demonstrate how late stage functionalization can be applied to these motifs to incorporate alkyne tags, generating fully functionalized probes for future chemical biology applications. Finally, we establish a workflow for determining the absolute configuration of enantioenriched vinyl sulfoximines and sulfonimidamides by comparing experimentally and computationally determined electronic circular dichroism spectra, enabling access to configurationally assigned enantiomeric pairs by separation